A Supramolecular Hydrogel Inspired by Elastin

Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel beating the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures,...

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Published inChinese journal of chemistry Vol. 29; no. 10; pp. 2182 - 2186
Main Author 丁磊 王淑芳 武文洁 胡月晗 杨翠红 谭鸣 孔德领 杨志谋
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.10.2011
WILEY‐VCH Verlag
Wiley
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Subjects
Chemistry
Chemistry, Multidisciplinary
hydrogel
Hydrogels
peptide
Physical Sciences
Science & Technology
self-assembly
supramolecular
弹力
弹性蛋白
水凝胶
生物功能材料
纳米结构
荧光显微镜
超分子
透射电子显微镜
DRUG
self-assembly
CELLS
supramolecular
peptide
ENZYME
NANOFIBERS
hydrogel
PH
RELEASE
SCAFFOLDS
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Summary:Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel beating the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures, and aromatic stacking in the self-assembled nanostructure were characterized by a rheometry, transmission electron microscope （TEM）, and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled-drug release, etc.
Bibliography:31-1547/O6
Ding, Lei Wang, Shufang Wu, Wenjie Hu, Yuehan Yang, Cuihong Tan, Ming Kong, Dehing Yang, Zhimou（ 1. Tianjin University of Science ＆ Technology, Tianjin 300457, China;2. Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China）
Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel beating the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures, and aromatic stacking in the self-assembled nanostructure were characterized by a rheometry, transmission electron microscope （TEM）, and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled-drug release, etc.
self-assembly, hydrogel, supramolecular, peptide
the National Natural Science Foundation of China - No. 31070856
the Tianjin Technology Support Project - No. 07ZCKFSH03600
ArticleID:CJOC201180378
istex:18D1A54D3FA8346BF49B54143A10238A12792432
ark:/67375/WNG-5MGB31QZ-Q
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201180378