Aqueous-mediated Michael Addition of Active Methylene Compounds with Nitroalkenes

A simple, atom economical and highly efficient green protocol has been developed for the synthesis of Michael adducts of nitroalkenes and 2-amino-2-chromene derivatives by Michael addition of active methylene compounds （such as malononitrile and ethyl cyanoacetate） to nitroalkenes under aqueous-medi...

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Bibliographic Details
Published inChinese journal of chemistry Vol. 30; no. 8; pp. 1771 - 1774
Main Author 董文凯 徐东成 谢建武
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.08.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Multidisciplinary
chromenes
domino reaction
green chemistry
Michael addition
Michael加成
nitroalkenes
Physical Sciences
Science & Technology
介导
催化
氰基乙酸乙酯
水
活性亚甲基化合物
硝基
迈克尔加成
Michael addition
nitroalkenes
ONE-STEP SYNTHESIS
ORGANIC-REACTIONS
CATALYST
green chemistry
SOLVENT
EFFICIENT METHOD
ACCELERATION
chromenes
MALONONITRILE
CHEMISTRY
domino reaction
TRANSFORMATIONS
WATER
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Summary:A simple, atom economical and highly efficient green protocol has been developed for the synthesis of Michael adducts of nitroalkenes and 2-amino-2-chromene derivatives by Michael addition of active methylene compounds （such as malononitrile and ethyl cyanoacetate） to nitroalkenes under aqueous-mediated conditions. This green approach provided the desired products in high yields and the reaction scope proved to be quite broad.
Bibliography:31-1547/O6
Michael addition, green chemistry, chromenes, nitroalkenes, domino reaction
Dong Wenkai, Xu Dongcheng, Xie Jianwu（ Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China）
A simple, atom economical and highly efficient green protocol has been developed for the synthesis of Michael adducts of nitroalkenes and 2-amino-2-chromene derivatives by Michael addition of active methylene compounds （such as malononitrile and ethyl cyanoacetate） to nitroalkenes under aqueous-mediated conditions. This green approach provided the desired products in high yields and the reaction scope proved to be quite broad.
the Program for Changjiang Scholars and Innovative Research Team in Chinese Universities - No. IRT0980
ark:/67375/WNG-GBGC226B-Q
ArticleID:CJOC201200228
istex:A5221CA89AC8EA10A61AD374450F9F9C22B00203
the National Natural Science Foundation of China - No. 20902083
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201200228