Convenient Synthesis of 3,5-Biscarbamoyl-pyridine Derivatives

An efficient and convenient method for synthesis of 3,5-bis-carbamoyl-2,6-dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5-bis（3＇,5＇-dimethy1-1＇-pyrazolyl-carbony1）-2,6- dimethylpyridine, in which pyrazoles served as leaving groups. The structure...

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Published inChinese journal of chemistry Vol. 29; no. 10; pp. 2119 - 2123
Main Author 汪霞云 朱逸雯 张敏 陆东亮 钱群 陈雅丽 曹卫国 宋力平 邓红梅
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.10.2011
WILEY‐VCH Verlag
Wiley
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Subjects
amide
aromatic amine
Chemistry
Chemistry, Multidisciplinary
heterocycles
Physical Sciences
Science & Technology
synthesis
二甲基吡啶
光谱数据
吡唑
吡啶衍生物
甲基衍生物
简便合成
synthesis
aromatic amine
amide
heterocycles
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Summary:An efficient and convenient method for synthesis of 3,5-bis-carbamoyl-2,6-dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5-bis（3＇,5＇-dimethy1-1＇-pyrazolyl-carbony1）-2,6- dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis.
Bibliography:31-1547/O6
An efficient and convenient method for synthesis of 3,5-bis-carbamoyl-2,6-dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5-bis（3＇,5＇-dimethy1-1＇-pyrazolyl-carbony1）-2,6- dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis.
heterocycles, amide, aromatic amine, synthesis
Wang, Xiayun Zhu, Yiwen Zhang, Min Lu, Dongliang Qian, Qun Chen, Yali Cao, Weiguo Song, Liping Deng, Hongmei（1. Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China ;2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;3. Instrumental Analysis and Research Center, Shanghai University, Shanghai 200444, China）
istex:49E0980C8CDA05BD64C47FE306889C2C4559AD44
ArticleID:CJOC201180367
the Leading Academic Discipline Project of Shanghai Municipal Education Commission - No. J50102
ark:/67375/WNG-6F69WWZS-2
the Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry
the Foundation of Education Commission of Shanghai Municipality - No. 08zz44
the National Natural Science Foundation of China - No. 20872086, 21072128
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201180367