Chiral Brønsted Acid Catalyzed Enantioselective Aza-Diels-Alder Reaction of Brassard's Diene with Imines
Brønsted, Brassard, Diels, and Alder: Aldimines 1 undergo aza‐Diels–Alder reactions with Brassard's diene 2 in the presence of a chiral cyclic phosphate pyridinium salt 4 as a chiral Brønsted acid to give α,β‐unsaturated δ‐lactams 3 with excellent enantioselectivity.
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Published in | Angewandte Chemie (International ed.) Vol. 45; no. 29; pp. 4796 - 4798 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
17.07.2006
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Brønsted, Brassard, Diels, and Alder: Aldimines 1 undergo aza‐Diels–Alder reactions with Brassard's diene 2 in the presence of a chiral cyclic phosphate pyridinium salt 4 as a chiral Brønsted acid to give α,β‐unsaturated δ‐lactams 3 with excellent enantioselectivity. |
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Bibliography: | istex:17885EE30603588D293DE014EEC7795558E6CB5A ark:/67375/WNG-BDRBRKGK-X We thank Professor Youichi Ishii and Dr. Yoshiaki Tanabe (Chuo University, Tokyo, Japan) for the X-ray structural determination. This work was partially supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, Culture, and Technology, Japan. J.I. is grateful for a JSPS Research Fellowship for Young Scientists. ArticleID:ANIE200601345 We thank Professor Youichi Ishii and Dr. Yoshiaki Tanabe (Chuo University, Tokyo, Japan) for the X‐ray structural determination. This work was partially supported by a Grant‐in‐Aid for Scientific Research from the Ministry of Education, Science, Sports, Culture, and Technology, Japan. J.I. is grateful for a JSPS Research Fellowship for Young Scientists. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200601345 |