Molecular Iodine Promoted Synthesis of New Pyrido[2,3-d]pyrimidin-4-ols

A highly efficient synthesis of novel pyrido[2,3-d]pyrimidin-4-ols was developed via an iodine-catalyzed tandem oxidative cyclization under focused microwave irradiation. Pyrido[2,3-d]pyrimidin-4-ols were obtained from easily available 2-amino-4-aryl-6-arylnicotinamides and benzylic amines with good...

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Bibliographic Details
Published inChinese journal of chemistry Vol. 29; no. 8; pp. 1646 - 1650
Main Author 王喜存 梁军灵 权正军 白林
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.08.2011
WILEY‐VCH Verlag
Wiley
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Subjects
3-d]pyrimidin-4-ol
Chemistry
Chemistry, Multidisciplinary
Iodine
iodine catalysis
microwave irradiation
OLS
oxidative cyclization
Physical Sciences
pyrido
pyrido[2,3‐d]pyrimidin‐4‐ol
Science & Technology
分子
吡啶
嘧啶
微波辐射
碘催化
芳基
高效合成
pyrido[2,3-d]pyrimidin-4-ol
DIURETIC ACTIVITY
iodine catalysis
microwave irradiation
KINASE INHIBITORS
oxidative cyclization
MICROWAVE CHEMISTRY
DERIVATIVES
DISCOVERY
SOLVENT
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Summary:A highly efficient synthesis of novel pyrido[2,3-d]pyrimidin-4-ols was developed via an iodine-catalyzed tandem oxidative cyclization under focused microwave irradiation. Pyrido[2,3-d]pyrimidin-4-ols were obtained from easily available 2-amino-4-aryl-6-arylnicotinamides and benzylic amines with good to excellent yields.
Bibliography:31-1547/O6
A highly efficient synthesis of novel pyrido[2,3-d]pyrimidin-4-ols was developed via an iodine-catalyzed tandem oxidative cyclization under focused microwave irradiation. Pyrido[2,3-d]pyrimidin-4-ols were obtained from easily available 2-amino-4-aryl-6-arylnicotinamides and benzylic amines with good to excellent yields.
iodine catalysis, oxidative cyclization, microwave irradiation, pyrido[2,3-d]pyrimidin-4-ol
the National Natural Science Foundation of China - No. 20902073
ArticleID:CJOC201180294
istex:76DB2D20682F8EC7975219C07AD1BFD3E7748505
the Natural Science Foundation of Gansu Province - No. 096RJZA116
ark:/67375/WNG-JDWGGDSX-F
Scientific and Technological Innovation Engineering Program of Northwest Normal University - No. nwnu-kjcxgc-03-64
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201180294