Gold-Catalyzed Direct Indolation of Tetrahydroisoquinolines

Nitrogen-containing heterocyclic compounds are important motifs of pharmaceuticals and functional materials, and there has been a growing interest in new synthetic methods for their preparations. In this paper, we report a direct cross-coupling reaction of indole with N-aryl tetrahydroisoquinolines...

Full description

Saved in:
Bibliographic Details
Published inChinese journal of chemistry Vol. 30; no. 12; pp. 2741 - 2746
Main Authors Zhang, Yan, Luo, Sha, Feng, Bainian, Zhu, Chengjian
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.12.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Multidisciplinary
CH activation
gold
heterocyclic compounds
indolation
N-芳基
Physical Sciences
R&D
Research & development
Science & Technology
sp3 bonds
交叉偶联反应
功能材料
合成方法
含氮杂环化合物
四氢异喹啉
金催化剂
黄金
SP C-H
TERTIARY-AMINES
C?H activation
CARBON-HYDROGEN BONDS
ORGANOGOLD COMPOUNDS
gold
indolation
OXIDATIVE MANNICH REACTION
sp3 bonds
DEHYDROGENATIVE-COUPLING CDC
NITROGEN ATOM
SODIUM-CYANIDE
heterocyclic compounds
MOLECULAR-OXYGEN
PET PROCESSES
Online AccessGet full text

Cover

More Information
Summary:Nitrogen-containing heterocyclic compounds are important motifs of pharmaceuticals and functional materials, and there has been a growing interest in new synthetic methods for their preparations. In this paper, we report a direct cross-coupling reaction of indole with N-aryl tetrahydroisoquinolines in the presence of gold catalyst. The reaction is compatible with a wide range of substituted indoles, to enable the tbrmation of various alkylated heteroarenest, nder very mild reaction conditions.
Bibliography:31-1547/O6
C-H activation; sp3 bonds; indolation; gold; heterocyclic compounds
Nitrogen-containing heterocyclic compounds are important motifs of pharmaceuticals and functional materials, and there has been a growing interest in new synthetic methods for their preparations. In this paper, we report a direct cross-coupling reaction of indole with N-aryl tetrahydroisoquinolines in the presence of gold catalyst. The reaction is compatible with a wide range of substituted indoles, to enable the tbrmation of various alkylated heteroarenest, nder very mild reaction conditions.
Zhang Yana, Luo sha, Feng Bainian,Zhu Cheng jian（ 1.School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, diangsu 214122, China b State Key Laboratory of Coordination Chemistry, School qfChemistty and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China）
istex:367936D60525B6F0B399969312386D3A6169AB1E
ArticleID:CJOC201201154
ark:/67375/WNG-GDNK87TJ-M
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201201154