Primary Central Nervous System Posttransplant Lymphoproliferative Disease in a Bilateral Transfemoral Lower Extremity Transplantation Recipient

• Published in: American journal of transplantation Vol. 15; no. 10; pp. 2758 - 2761
• Main Authors: Cavadas, P. C., Thione, A., Blanes, M., Mayordomo‐Aranda, E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.10.2015
• Subjects: cancer; Case reports; Cell proliferation; Central nervous system; Central Nervous System Diseases - diagnosis; Central Nervous System Diseases - etiology; Clinical decision making; Clinical research; practice; Humans; Leg - transplantation; Lymphatic diseases; Lymphocytes; Lymphoproliferative Disorders - diagnosis; Lymphoproliferative Disorders - etiology; Male; malignancy; neoplasia, clinical decision‐making; Nervous system; Postoperative Complications - diagnosis; Posttransplant lymphoproliferative disorders; Transplantation; Transplants & implants; Vascularized Composite Allotransplantation; vascularized composite and reconstructive transplantation; Xenotransplantation; Young Adult; neoplasia, clinical decision-making; cancer; vascularized composite and reconstructive transplantation; malignancy; Clinical research; practice
• ISSN: 1600-6135; 1600-6143
• DOI: 10.1111/ajt.13313

Posttransplant lymphoproliferative disorder (PTLD) is a heterogeneous group of clinical and pathological entities characterized by malignant lymphoid cell proliferation occurring after solid organ transplantation, with frequent extranodal involvement. Central nervous system (CNS) involvement occurs in 7–15% of the cases and it is a significant negative prognostic factor. A case of primary CNS (PCNS) PTLD in the first bilateral lower limb transplant recipient is presented. The authors present a case of primary central nervous system posttransplant lymphoproliferative disease in the first bilateral lower limb transplant recipient.