Increased sFlt-1 to PlGF ratio in women who subsequently develop preeclampsia

• Published in: Journal of Korean medical science Vol. 22; no. 5; pp. 873 - 877
• Main Authors: Kim, Shin-Young, Ryu, Hyun-Mee, Yang, Jae-Hyug, Kim, Moon-Young, Han, Jung-Yeol, Kim, Joo-Oh, Chung, Jin-Hoon, Park, So-Yeon, Lee, Moon-Hee, Kim, Do-Jin
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.10.2007
• Subjects: Adult; Biomarkers - metabolism; Case-Control Studies; Female; Humans; Immunoassay; Middle Aged; Original; Placenta - metabolism; Placenta Growth Factor; Pre-Eclampsia - diagnosis; Pre-Eclampsia - metabolism; Pregnancy; Pregnancy Proteins - biosynthesis; Pregnancy Trimester, Second; ROC Curve; Sensitivity and Specificity; Vascular Endothelial Growth Factor Receptor-1 - biosynthesis
• ISSN: 1011-8934; 1598-6357
• DOI: 10.3346/jkms.2007.22.5.873

The purpose of this study was to determine whether the levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) are altered during the second trimester in the plasma of women who subsequently develop preeclampsia. We performed a case-control study to compare the levels of sFlt-1 and PlGF in the preeclamptic (n=46) and normal pregnant women (n=100). The maternal plasma levels of sFlt-1 and PlGF were measured by enzyme-linked immunosorbent assay. The sFlt-1 levels were significantly higher in the preeclamptic women than in normal controls (p<0.001), while the PlGF levels were significantly lower (p<0.001). In normal controls, sFlt-1 levels were positively correlated (r=0.27, p=0.008), whereas, in the preeclamptic women, those were negatively correlated with the PlGF levels (r=-0.423, p=0.005). Furthermore, the log[sFlt-1/PlGF] ratio was significantly higher in the preeclamptic women than in normal controls (p<0.001). The receiver operating characteristic curve revealed a specificity of 78% with a diagnostic sensitivity of 80.4%; the optimal cut-off value of the log[sFlt-1/PlGF] ratio was 1.4 (95% CI 0.756-0.910, p<0.001). Preeclampsia showed a strong association with increased levels of sFlt-1 and decreased levels of PlGF in the second trimester maternal plasma. Accordingly, the sFlt-1/PlGF ratio may provide early prediction of subsequent development of preeclampsia.