A stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor

We present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.

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Bibliographic Details
Published inRisk analysis Vol. 8; no. 3; p. 383
Main Authors Moolgavkar, S H, Dewanji, A, Venzon, D J
Format Journal Article
LanguageEnglish
Published United States 01.09.1988
Subjects
Carcinogens
Cocarcinogenesis
Humans
Models, Statistical
Neoplasms - etiology
Risk
Stochastic Processes
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Summary:We present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1988.tb00502.x