Adjustment of the γ Dihedral Angle of an Oligonucleotide P3′→N5′ Phosphoramidate Enhances Its Binding Affinity towards Complementary Strands
Bridge to the right angle: A methylene bridge between the C3′ and N5′ atoms restricts the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate within the +sc orientation (see scheme), which improves duplex‐forming ability and accelerates hydrolytic cleavage.
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Published in | Angewandte Chemie (International ed.) Vol. 44; no. 13; pp. 1944 - 1947 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
18.03.2005
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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