Adjustment of the γ Dihedral Angle of an Oligonucleotide P3′→N5′ Phosphoramidate Enhances Its Binding Affinity towards Complementary Strands
Bridge to the right angle: A methylene bridge between the C3′ and N5′ atoms restricts the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate within the +sc orientation (see scheme), which improves duplex‐forming ability and accelerates hydrolytic cleavage.
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Published in | Angewandte Chemie (International ed.) Vol. 44; no. 13; pp. 1944 - 1947 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
18.03.2005
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Bridge to the right angle: A methylene bridge between the C3′ and N5′ atoms restricts the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate within the +sc orientation (see scheme), which improves duplex‐forming ability and accelerates hydrolytic cleavage. |
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Bibliography: | istex:D17EADFE8A8D58CDE3BD69F784DA5FD346422FA8 ark:/67375/WNG-89CSD4SX-K This research was partially supported by a Grant-in-Aid from the Japan Society for the Promotion of Science, a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a SUNBOR Grant from the Suntory Institute for Bioorganic Research. We gratefully acknowledge a JSPS Research Fellowship for Young Scientists (M.S.). ArticleID:ANIE200461942 This research was partially supported by a Grant‐in‐Aid from the Japan Society for the Promotion of Science, a Grant‐in‐Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a SUNBOR Grant from the Suntory Institute for Bioorganic Research. We gratefully acknowledge a JSPS Research Fellowship for Young Scientists (M.S.). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200461942 |