A rare melanoma feature with primary ovarian origin: a case report and the literature review

• Published in: Obstetrics & gynecology science Vol. 61; no. 2; pp. 282 - 285
• Main Authors: Paola, Algeri, Maria, Rota Sonia, Laura, Carlini, Elena, Nicoli, Orlando, Caruso, Teresio, Motta
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 01.03.2018; Korean Society of Obstetrics and Gynecology; 대한산부인과학회
• Subjects: Case Report; melanoma; ovarian cancer; teratoma; 산부인과학; Teratoma; Melanoma; Ovarian cancer
• ISSN: 2287-8572; 2287-8580
• DOI: 10.5468/ogs.2018.61.2.282

Primary ovarian melanoma arising on a mature ovarian cystic teratoma is extremely rare. As best of our knowledge, to date, 49 cases have been reported in literature. Few information was reported about best management and therapy. We present a case occurred in a 69-year-old woman, without symptoms, who come to our unit for stress incontinence. A pelvic mass was detected and, after imaging evaluation, surgery was performed. The diagnosis was ovarian melanoma arose on a mature teratoma. No other adjuvant treatment was proposed after surgery. She died 9 months after the first diagnosis. Primary ovarian melanoma is a definite entity associated with a variable natural history and poor prognosis. Differential diagnosis is a challenge for the pathologist, because it must be differentiated by metastatic melanoma. The corner stone treatment of this disease is surgery; however, chemotherapy, immunotherapy, and target therapy seem to have a role.