Manifestations of three HHV‐8‐related diseases in an HIV‐negative patient: Immunoblastic variant multicentric Castleman's disease, primary effusion lymphoma, and Kaposi's sarcoma

• Published in: American journal of hematology Vol. 65; no. 4; pp. 310 - 314
• Main Authors: Codish, Shlomi, Abu‐Shakra, Mahmoud, Ariad, Samuel, Zirkin, Howard J., Yermiyahu, Tikva, Dupin, Nicolas, Boshoff, Chris, Sukenik, Shaul
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.12.2000; Wiley-Liss
• Subjects: Aged; Biological and medical sciences; Castleman Disease - complications; Castleman Disease - virology; Castleman's disease; Female; Hematologic and hematopoietic diseases; Herpesvirus 8, Human - isolation & purification; HIV Seronegativity; Humans; hypoglycemia; Hypoglycemia - etiology; Hypoglycemia - virology; Kaposi's sarcoma; Kaposi's sarcoma‐associated herpesvirus; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma - complications; Lymphoma - virology; Medical sciences; primary effusion lymphoma; Sarcoma, Kaposi - complications; Sarcoma, Kaposi - virology; Tropical medicine; Human; Benign lymphadenopathy; Skin disease; Herpesviridae; Alphaherpesvirinae; Hemopathy; Malignant tumor; Infection; Virus; Case study; Kaposi sarcoma; Lymphoproliferative syndrome; Viral disease; Complication; Female; Malignant lymphoma; Herpesvirus hominis; Castleman lymphoma; Elderly
• ISSN: 0361-8609; 1096-8652
• DOI: 10.1002/1096-8652(200012)65:4<310::AID-AJH11>3.0.CO;2-G

We describe a 73‐year‐old HIV negative patient who presented with symptomatic hypoglycemia. Over the course of several months she was diagnosed with three human herpesvirus‐8 related diseases: multicentric Castleman's disease, primary effusion lymphoma and Kaposi's sarcoma. No improvement was observed following cytotoxic therapy and she died 16 months after her initial presentation. The etiology of the hypoglycemia remained obscure over the course of this patient's disease. This case is the first report of a patient with three human herpesvirus‐8 related diseases, and the first report of severe hypoglycemia as the presenting symptom of any of these diseases. Am. J. Hematol. 65:310–314, 2000. © 2000 Wiley‐Liss, Inc.