In Situ Polymerized Hydrogels for Repairing Scleral Incisions Used in Pars Plana Vitrectomy Procedures

New lysine‐based dendrimers which upon reaction with a poly(ethylene glycol) di‐activated ester afford a soft flexible hydrogel that can be used to seal a wound in the sclerotomy. These wounds are made during the common ophthalmic procedure of a vitrectomy. The rheological and swelling properties of...

Full description

Saved in:
Bibliographic Details
Published inChemMedChem Vol. 1; no. 8; pp. 821 - 825
Main Authors Wathier, Michel, Johnson, M. Starck, Carnahan, Michael A., Baer, Claxton, McCuen, Brooks W., Kim, Terry, Grinstaff, Mark W.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.08.2006
WILEY‐VCH Verlag
Subjects
Adhesives - chemical synthesis
Adhesives - chemistry
Adhesives - pharmacology
Animals
dendrimers
Dendrimers - chemical synthesis
Dendrimers - chemistry
hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Hydrogels - pharmacology
materials
ophthalmology
polymers
Sclera - surgery
Swine
Vitrectomy
Wound Healing - drug effects
Online AccessGet full text

Cover

More Information
Summary:New lysine‐based dendrimers which upon reaction with a poly(ethylene glycol) di‐activated ester afford a soft flexible hydrogel that can be used to seal a wound in the sclerotomy. These wounds are made during the common ophthalmic procedure of a vitrectomy. The rheological and swelling properties of the hydrogel can be tuned by either changing the concentration, the type, and/or the generation of the dendrimers.
Bibliography:This work was supported by the NIH NEI.
istex:35FA44E233A6BCAB84913E9839DDFEA66AA143A1
ark:/67375/WNG-3DZFFJNW-R
ArticleID:CMDC200600090
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200600090