Chemical Components of Dendrobium chrysotoxum

Two new phenanthrenes, named chrysotoxols A and B （1, 2） and 24 known compounds were isolated from the stems of the accession species in 2010 Chinese Pharmacopoeia of＂Shihu＂, Dendrobium chrysotoxum. All structures were elucidated by spectroscopic （NMR, MS, UV and IR） methods and the comparison with...

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Published inChinese journal of chemistry Vol. 30; no. 6; pp. 1327 - 1330
Main Author 胡江苗 范卫卫 董发武 缪泽鸿 周俊
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.06.2012
WILEY‐VCH Verlag
Wiley
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Subjects
A549细胞
Chemistry
Chemistry, Multidisciplinary
chrysotoxol
cytotoxic activity
Dendrobium chrysotoxum
HL-60
Orchidaceae
phenanthrene
Physical Sciences
Science & Technology
中国药典
化合物
化学成分
石斛
细胞毒活性
结构鉴定
GLYCOSIDES
Dendrobium chrysotoxum
PHENANTHRENES
BIBENZYLS
Orchidaceae
STILBENOIDS
cytotoxic activity
chrysotoxol
phenanthrene
CONSTITUENTS
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Summary:Two new phenanthrenes, named chrysotoxols A and B （1, 2） and 24 known compounds were isolated from the stems of the accession species in 2010 Chinese Pharmacopoeia of＂Shihu＂, Dendrobium chrysotoxum. All structures were elucidated by spectroscopic （NMR, MS, UV and IR） methods and the comparison with reported data in the literatures. Compound 2 and six known phenols were assessed for cytotoxic activity against two human tumor cell lines （A549 and HL-60）. The results indicated that erianin may have cytotoxic activity and the other six compounds lost activity at the concentration down to 10^-5 mol·L^-1.
Bibliography:31-1547/O6
Orchidaceae, Dendrobium chrysotoxum, chrysotoxol, phenanthrene, cytotoxic activity
Two new phenanthrenes, named chrysotoxols A and B （1, 2） and 24 known compounds were isolated from the stems of the accession species in 2010 Chinese Pharmacopoeia of＂Shihu＂, Dendrobium chrysotoxum. All structures were elucidated by spectroscopic （NMR, MS, UV and IR） methods and the comparison with reported data in the literatures. Compound 2 and six known phenols were assessed for cytotoxic activity against two human tumor cell lines （A549 and HL-60）. The results indicated that erianin may have cytotoxic activity and the other six compounds lost activity at the concentration down to 10^-5 mol·L^-1.
Hu, Jiangmiao Fan, Weiwei Dong, Fawu Miao, Zehong Zhou, Jun
the National Natural Science Foundation of China - No. 30800090
istex:6CB50D0D3905D91BDE2EB67BD14D689DC28B1FE6
ark:/67375/WNG-3Q2V4M7X-X
ArticleID:CJOC201100670
the Foundation of State Key Laboratory of Phytochemistry and Plant Resource in West China - No. P2010-ZZ012
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201100670