Red blood cell membrane-functionalized Nanofibrous tubes for small-diameter vascular grafts

• Published in: Biomaterials Vol. 297; p. 122124
• Main Authors: Zhang, Chunliang, Cha, Ruitao, Wang, Chunyuan, Chen, Xingming, Li, Zulan, Xie, Qian, Jia, Liujun, Sun, Yang, Hu, Zhan, Zhang, Lin, Zhou, Fengshan, Zhang, Yan, Jiang, Xingyu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2023
• Subjects: Animals; Biocompatible Materials; Blood Vessel Prosthesis; Cell Membrane; Electrospinning; Nanofibers; Personalized therapy; Poly-ε-caprolactone; Polyesters; Rabbits; Red blood cell membrane; Small-diameter vascular graft; Tissue Scaffolds; Vascular Grafting; Electrospinning; Small-diameter vascular graft; Poly-ε-caprolactone; Personalized therapy; Red blood cell membrane
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2023.122124

The off-the-shelf small-diameter vascular grafts (SDVGs) have inferior clinical efficacy. Red blood cell membrane (Rm) has easy availability and multiple bioactive components (such as phospholipids, proteins, and glycoproteins), which can improve the clinic's availability and patency of SDVGs. Here we developed a facile approach to preparing an Rm-functionalized poly-ε-caprolactone/poly-d-lysine (Rm@PCL/PDL) tube by co-incubation and single-step rolling. The integrity, stability, and bioactivity of Rm on Rm@PCL/PDL were evaluated. The revascularization of Rm@PCL/PDL tubes was studied by implantation in the carotid artery of rabbits. Rm@PCL/PDL can be quickly prepared and showed excellent bioactivity with good hemocompatibility and great anti-inflammatory. Rm@PCL/PDL tubes as the substitute for the carotid artery of rabbits had good patency and quick remodeling within 21 days. Rm, as a “self” biomaterial with high biosafety, provides a new and facile approach to developing personalized or universal SDVGs for the clinic, which is of great significance in cardiovascular regenerative medicine and organ chip.