Iris melanoma: Review of clinical features, risks, management, and outcomes

• Published in: Clinics in dermatology Vol. 42; no. 1; pp. 62 - 70
• Main Authors: Cherkas, Elliot, Kalafatis, Nicholas E., Marous, Molly R., Shields, Carol L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2024
• Subjects: Adult; Humans; Iris - pathology; Iris Neoplasms - pathology; Iris Neoplasms - therapy; Longitudinal Studies; Melanoma - diagnosis; Melanoma - epidemiology; Melanoma - therapy; Nevus, Pigmented; Skin Neoplasms - pathology; Uveal Neoplasms - epidemiology; Uveal Neoplasms - pathology; Uveal Neoplasms - therapy
• ISSN: 0738-081X; 1879-1131
• DOI: 10.1016/j.clindermatol.2023.10.009

Primary uveal melanoma is rare and affects approximately 8,000 persons per year worldwide. This malignancy can involve the iris, ciliary body, and choroid. Of these three structures, the iris is the least commonly affected site, representing only 4% of all uveal melanomas. Iris melanoma can arise from iris melanocytic nevus, iris melanocytosis, or de novo. In a longitudinal study of 1,611 patients with iris nevus, transformation into melanoma, using Kaplan-Meier estimates, was found in 2.6% by five years and in 4.1% by 10 years. The factors that predicted growth of iris melanocytic nevus into melanoma are denoted by a letter (ABCDEF) guide: A for age ≤40 years old at presentation (hazard ratio [HR] = 3, P = .01), B for blood (hyphema) (HR = 9, P < .0004), C for clock hour of tumor inferiorly (tumor location) (HR = 9, P = .03), D for diffuse flat tumor configuration (HR = 14, P = .02), E for ectropion uveae (HR = 4, P = .002), and F for feathery ill-defined margins (HR = 3, P = .02). At diagnosis, iris melanoma has a mean cross-sectional diameter of 5.5 mm and thickness of 2.1 mm, often with tumor seeding (28%) and secondary glaucoma (35%). We provide a comprehensive review of iris nevus and melanoma to explore relevant demographic and clinical data, risk factors for tumor growth, management, and prognosis, with the hope that clinicians will be more comfortable in understanding this rare malignant condition.