Synthesis of New Glucosylated Porphyrins Bearing an α-d-Linkage

This paper presents the synthesis of two new glucosyl tritolylporphyrins in which the carbohydrate moiety is connected through a carboxymethyl glycosidic α-D-linkage. These compounds have been obtained by reaction between porphyrins bearing an amino function with a lactone prepared from the availabl...

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Bibliographic Details
Published inJournal of carbohydrate chemistry Vol. 25; no. 4; pp. 345 - 360
Main Authors Sol, Vincent, Charmot, Alexandre, Krausz, Pierre, Trombotto, Stéphane, Queneau, Yves
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.06.2006
Taylor & Francis
Subjects
Biochemistry & Molecular Biology
Chemical Sciences
Chemistry
Chemistry, Organic
Isomaltulose
Life Sciences & Biomedicine
Organic chemistry
Photodynamic therapy
Physical Sciences
Porphyrins
Science & Technology
α-D-glucose
SINGLET OXYGEN
isomaltulose
DERIVATIVES
photodynamic therapy
porphyrins
alpha-D-glucose
α‐D‐glucose
Isomaltulose
Photodynamic therapy
Porphyrins
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Summary:This paper presents the synthesis of two new glucosyl tritolylporphyrins in which the carbohydrate moiety is connected through a carboxymethyl glycosidic α-D-linkage. These compounds have been obtained by reaction between porphyrins bearing an amino function with a lactone prepared from the available disaccharide isomaltulose. The photocytotoxicity of these compounds against K562 human chronic myelogenous leukemia cells has been evaluated in comparison to Photofrin II.
ISSN:0732-8303
1532-2327
DOI:10.1080/07328300600770527