Sonic Hedgehog Activates Mesenchymal Gli1 Expression during Prostate Ductal Bud Formation

• Published in: Developmental biology Vol. 249; no. 2; pp. 349 - 366
• Main Authors: Lamm, Marilyn L.G, Catbagan, Winnie S, Laciak, Robert J, Barnett, Daniel H, Hebner, Christy M, Gaffield, William, Walterhouse, David, Iannaccone, Philip, Bushman, Wade
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2002
• Subjects: Animals; Base Sequence; Cell Division; cyclopamine; Dihydrotestosterone - pharmacology; Diosgenin; DNA Primers; ductal budding; Embryonic and Fetal Development - physiology; Epithelial Cells - cytology; Epithelium - embryology; Gene Expression Regulation, Developmental - drug effects; Gli; Hedgehog Proteins; In Situ Hybridization; Male; Mesoderm - physiology; Mice; Oncogene Proteins - genetics; Organ Culture Techniques - methods; Prostate - cytology; Prostate - embryology; prostate development; Ptc1; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - physiology; Solanaceous Alkaloids - pharmacology; Sonic hedgehog; Trans-Activators - drug effects; Trans-Activators - genetics; Trans-Activators - physiology; Transcription Factors - genetics; urogenital sinus; Veratrum Alkaloids - pharmacology; Zinc Finger Protein GLI1; Zinc Fingers; Sonic hedgehog; Ptc1; Gli; ductal budding; prostate development; urogenital sinus; cyclopamine

Ductal budding in the developing prostate is a testosterone-dependent event that involves signaling between the urogenital sinus epithelium (UGE) and urogenital sinus mesenchyme (UGM). We show here that ductal bud formation is associated with focused expression of Sonic hedgehog ( Shh) in the epithe...