Electrospun xanthan gum-chitosan nanofibers as delivery carrier of hydrophobic bioactives

•Electrospinning of viscoelastic gels of xanthan gum-chitosan.•Production of stable electrospun xanthan-chitosan nanofibers in aqueous media.•Novel carrier for the encapsulation and controlled release of hydrophobic bioactives. Viscoelastic gels of xanthan gum-chitosan(X-Ch) in formic acid were elec...

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Bibliographic Details
Published inMaterials letters Vol. 228; pp. 322 - 326
Main Authors Shekarforoush, Elhamalsadat, Ajalloueian, Fatemeh, Zeng, Guanghong, Mendes, Ana C., Chronakis, Ioannis S.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.10.2018
Elsevier BV
Subjects
Biological activity
Chitosan
Curcumin
Dietary fiber
Drug delivery
Drug delivery systems
Electrospinning
Encapsulation
Formic acid
Gels
Materials science
Nanofibers
Nanomaterials
Viscoelasticity
Xanthan
Xanthan gum
Xanthan gum
Electrospinning
Drug delivery
Curcumin
Chitosan
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Summary:•Electrospinning of viscoelastic gels of xanthan gum-chitosan.•Production of stable electrospun xanthan-chitosan nanofibers in aqueous media.•Novel carrier for the encapsulation and controlled release of hydrophobic bioactives. Viscoelastic gels of xanthan gum-chitosan(X-Ch) in formic acid were electrospun to produce nanofibers, stable in aqueous media, for the encapsulation and release of curcumin (Cu). After 120 h, the nanofibers released lower amount of curcumin (∼20%) at pH 2.2 comparatively to the release in neutral media (∼50%), suggesting that X-Ch nanofibers could be used as a carrier for the encapsulation of hydrophobic bioactive compounds with long-term pH-stimulated release properties.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2018.06.033