The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model

C-peptide is produced, processed, and secreted with insulin, and appears to exert separate but intimately related effects. In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-p...

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Bibliographic Details
Published inPhysiology (Bethesda, Md.) Vol. 30; no. 4; pp. 327 - 332
Main Authors Yosten, Gina L C, Kolar, Grant R
Format Journal Article
LanguageEnglish
Published United States 01.07.2015
Subjects
Animals
C-Peptide - metabolism
Diabetic Angiopathies - metabolism
Diabetic Angiopathies - physiopathology
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Humans
Insulin - metabolism
Insulin Secretion
Insulin-Secreting Cells - metabolism
Models, Biological
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
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Summary:C-peptide is produced, processed, and secreted with insulin, and appears to exert separate but intimately related effects. In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-peptide.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00008.2015