Green route synthesis of 4-thiazolidinone analogs of isonicotinic acid hydrazide

The broad and potent activity of 4-thiazolidinones has established it as one of the biologically important scaffolds. The synthesis of N-(2-aryl-4-oxothiazolidin-3-yl)isonicotinamide by a novel method of stirring and sonication is described. The conventional method for synthesis of 4-thiazolidinones...

Full description

Saved in:
Bibliographic Details
Published inGreen chemistry letters and reviews Vol. 4; no. 3; pp. 211 - 217
Main Authors Thomas, Asha B., Sharma, Piyoosh A., Tupe, Preeti N., Badhe, Ravindra V., Nanda, Rabindra K., Kothapalli, Lata P., Paradkar, Omkar D., Banerjee, Anupam G., Deshpande, Avinash D.
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis Group 01.09.2011
Taylor & Francis Ltd
Subjects
4-thiazolidinones
Green chemistry
sonication
stirring
Online AccessGet full text

Cover

More Information
Summary:The broad and potent activity of 4-thiazolidinones has established it as one of the biologically important scaffolds. The synthesis of N-(2-aryl-4-oxothiazolidin-3-yl)isonicotinamide by a novel method of stirring and sonication is described. The conventional method for synthesis of 4-thiazolidinones involves use of a Dean-Stark water separator for the removal of water from the reaction with long reaction times (12-48 h), and the stirring procedure also involves the use of DCC (dicyclohexylcarbodiimide) as a dehydrating agent. We report the synthesis of 4-thiazolidinone analogs of isonicotinic acid hydrazide by novel, green route methods of sonication and stirring using molecular sieves. Results indicate that high yields and shorter reaction times can be achieved by employing novel green route methods of synthesis.
ISSN:1751-8253
1751-7192
DOI:10.1080/17518253.2010.544261