Relationship Between Hematotoxicity and Serum Albumin Level in the Treatment of Head and Neck Cancers with Concurrent Chemoradiotherapy Using Cisplatin

• Published in: Japanese journal of clinical oncology Vol. 41; no. 8; pp. 973 - 979
• Main Authors: Ishizuka, Masako, Fujimoto, Yasushi, Itoh, Yoshiyuki, Kitagawa, Koichi, Sano, Motoki, Miyagawa, Yasuhiro, Ando, Atsushi, Hiramatsu, Mariko, Hirasawa, Naoki, Ishihara, Shunichi, Nakashima, Tsutomu, Yamada, Kiyofumi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2011
• Subjects: Adult; Aged; Anemia - chemically induced; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Body Mass Index; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Cisplatin - adverse effects; Cisplatin - therapeutic use; Combined Modality Therapy; Dermatitis - etiology; Female; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - radiotherapy; Hemoglobins - metabolism; Humans; Leukocyte Count; Leukopenia - chemically induced; Male; Middle Aged; Mucositis - etiology; Neutropenia - chemically induced; Radiotherapy - adverse effects; Regression Analysis; Retrospective Studies; Serum Albumin - metabolism; radiotherapy; neutropenia; serum albumin level; correlation; chemotherapy; completion rate
• ISSN: 0368-2811; 1465-3621
• DOI: 10.1093/jjco/hyr076

Objective Patients with locally advanced head and neck cancer were treated with concurrent chemoradiotherapy using three courses of cisplatin. However, many patients were unable to complete the scheduled cisplatin treatment due to adverse effects. The objective of this study was to retrospectively elucidate the source of the low completion rate of cisplatin courses. Methods Between November 2007 and 28 May 2010, patients with head and neck cancer were treated with curative intent according to the concurrent chemoradiotherapy protocol (66-70 Gy at 2 Gy/day with cisplatin 80 mg/m2 on Days 1, 22 and 43). Treatment courses, hematological data and other parameters were investigated, and the treatment completion rates and reasons for treatment failure were analyzed. Results Among the 28 patients, cisplatin was administered during the period of radiotherapy a total of 3 times in 9 (32%) patients, 2 times in 15 (54%) patients and only 1 time in 4 (14%) patients. Multiple regression analysis of the development of neutropenia at 3 weeks after the first cisplatin administration revealed that the serum albumin level was a significant explanatory variable (R 2= 0.664, β = 0.517, P< 0.01). Pearson's product-moment correlation coefficient showed a strong correlation between the serum albumin level and the neutrophil count after 3 weeks (r = 0.605, P< 0.01). Conclusions The treatment completion rate by this protocol was low in head and neck cancer patients even when the cisplatin dose was reduced to 80 mg/m2. This tendency was seen in patients with a low serum albumin level.