Sporulation of Bacillus subtilis

Differentiation of vegetative Bacillus subtilis into heat resistant spores is initiated by the activation of the key transcription regulator Spo0A through the phosphorelay. Subsequent events depend on the cell compartment-specific action of a series of RNA polymerase σ factors. Analysis of genes in...

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Bibliographic Details
Published inCurrent opinion in microbiology Vol. 7; no. 6; pp. 579 - 586
Main Authors Piggot, Patrick J, Hilbert, David W
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2004
Subjects
Bacillus subtilis
Bacillus subtilis - genetics
Bacillus subtilis - metabolism
Bacillus subtilis - physiology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Gene Expression Regulation, Bacterial
Spores, Bacterial - physiology
Transcription, Genetic
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Summary:Differentiation of vegetative Bacillus subtilis into heat resistant spores is initiated by the activation of the key transcription regulator Spo0A through the phosphorelay. Subsequent events depend on the cell compartment-specific action of a series of RNA polymerase σ factors. Analysis of genes in the Spo0A regulon has helped delineate the mechanisms of axial chromatin formation and asymmetric division. There have been considerable advances in our understanding of critical controls that act to regulate the phosphorelay and to activate the σ factors.
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ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2004.10.001