Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report

Pemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapilla...

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Bibliographic Details
Published inIndian journal of pathology & microbiology Vol. 66; no. 4; pp. 852 - 854
Main Authors Kavita, Rawat, Sheenam, Azad, Neelima, Bahal, Jitender, Bisht S
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.10.2023
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
Antibodies
Dapsone
desmoglein1
Diaminodiphenylsulfone
direct immunofluorescence
Elongation
Epidermis
Fluorescent antibody technique
Histopathology
Immunofluorescence
Immunoglobulin A
Immunoglobulin G
indirect immunofluorescence
Leukocytes (neutrophilic)
Pemphigus
pemphigus herpetiformis
Skin
Skin diseases
Steroid hormones
Ulcers
direct immunofluorescence
indirect immunofluorescence
pemphigus herpetiformis
Desmoglein1
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Summary:Pemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA deposits along basement zone. Indirect immunofluorescence (IIF) revealed antibodies to desmoglein1 (Dsg-1) positive. A final diagnosis of PH was given. The patient responded well to treatment with dapsone and steroids.
ISSN:0377-4929
0974-5130
DOI:10.4103/IJPM.IJPM_879_20