Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis

• Published in: Cell research Vol. 27; no. 10; pp. 1216 - 1230
• Main Authors: Lin, Zhen, Hsu, Phillip J, Xing, Xudong, Fang, Jianhuo, Lu, Zhike, Zou, Qin, Zhang, Ke-Jia, Zhang, Xiao, Zhou, Yuchuan, Zhang, Teng, Zhang, Youcheng, Song, Wanlu, Jia, Guifang, Yang, Xuerui, He, Chuan, Tong, Ming-Han
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2017; Nature Publishing Group
• Subjects: 631/136/2434/1822; 631/337/574; 631/80/86; Biomedical and Life Sciences; Cell Biology; Cell proliferation; Clonal deletion; Deactivation; Depletion; Developmental stages; Differentiation; Gene expression; Germ cells; Inactivation; Life Sciences; Mice; mRNA; N6-methyladenosine; Original; original-article; Pachytene; Post-transcription; Ribonucleic acid; RNA; RNA modification; Rodents; Spermatids; Spermatocytes; Spermatogenesis; Spermatogonia; Spermatozoa; Spermiogenesis; SSCS; Stem cell transplantation; Stem cells; Transcription; Translation; 分化过程; 基因表达调控; 生殖细胞; 突变小鼠; 精原细胞; 精子发生过程; A RNA modification; spermatogonial stem cell; spermiogenesis; Mettl3; Mettl14; m

Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells （SSCs） produce hap- loid spermatozoa. This highly specialized process is precisely controlled at the transcriptional, posttranscriptional, and translational levels. Here we report that N6-methyladenosine （m6A...