Progress in high throughput SNP genotyping methods

Most current single nucleotide polymorphism (SNP) genotyping methods are still too slow and expensive for routine use in large association studies with hundreds or more SNPs in a large number of DNA samples. However, SNP genotyping technology is rapidly progressing with the emergence of novel, faste...

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Bibliographic Details
Published inThe pharmacogenomics journal Vol. 2; no. 2; pp. 103 - 110
Main Authors TSUCHIHASHI, Z, DRACOPOLI, N. C
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing 2002
Nature Publishing Group
Subjects
Animals
Biological and medical sciences
Diverse techniques
Fundamental and applied biological sciences. Psychology
Genome-wide association studies
Genomes
Genomics - methods
Genomics - trends
Genotype
Genotyping
Haplotypes
Humans
Molecular and cellular biology
Polymorphism, Single Nucleotide - genetics
Single-nucleotide polymorphism
High throughput screening
Genotype
Review
Single nucleotide polymorphism
Investigation method
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Summary:Most current single nucleotide polymorphism (SNP) genotyping methods are still too slow and expensive for routine use in large association studies with hundreds or more SNPs in a large number of DNA samples. However, SNP genotyping technology is rapidly progressing with the emergence of novel, faster and cheaper methods as well as improvements in the existing methods. In this review, we focus on technologies aimed at high throughput uses, and discuss the technical advances made in this field in the last few years. The rapid progress in technology, in combination with the discovery of millions of SNPs and the development of the human haplotype map, may enable whole genome association studies to be initiated in the near future.
Bibliography:ObjectType-Article-2
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ISSN:1470-269X
1473-1150
DOI:10.1038/sj.tpj.6500094