Genes that drive invasion and migration in Drosophila

Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss re...

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Bibliographic Details
Published inCurrent opinion in genetics & development Vol. 14; no. 1; pp. 86 - 91
Main Authors Starz-Gaiano, Michelle, Montell, Denise J
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2004
Subjects
Animals
Cell Adhesion - genetics
Cell Adhesion - physiology
Cell Movement - genetics
Cell Movement - physiology
Cytoskeleton - genetics
Cytoskeleton - physiology
Drosophila
Drosophila - genetics
Receptor Protein-Tyrosine Kinases - physiology
FOI
PVF
Dome
VEGF
RTK
SDF-1
Upd
FGFR
PVR
EGFR
STAT
JAK
PDGF
E-cad
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Summary:Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in understanding the migration of the ovarian border cells, embryonic blood cells, primordial germ cells, somatic gonadal precursors, and tracheal cells. Comparison of genes that regulate these processes to those that promote tumorigenesis and metastasis in mammals demonstrates that studies in fruit flies are uncovering new genes highly relevant to cancer biology.
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ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2003.12.001