Asymmetric intermolecular Stetter reactions catalyzed by a novel triazolium derived N-heterocyclic carbene

The asymmetric intermolecular Stetter reaction is catalyzed by a novel triazolium salt derived N-heterocyclic carbene leading to 1,4-diketones in moderate to excellent yields (49-98%) and moderate to good enantioselectivities (56-78% ee), which could be enhanced by one recrystallization to excellent...

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 34; pp. 3989 - 3991
Main Authors Enders, Dieter, Han, Jianwei, Henseler, Alexander
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.09.2008
Subjects
carbenes
catalytic activity
chemical reactions
Chemistry
Chemistry, Multidisciplinary
crystallization
enantioselectivity
heterocyclic nitrogen compounds
Physical Sciences
Science & Technology
ENANTIOSELECTIVE SYNTHESIS
BENZOIN REACTIONS
ACYLATION
SCOPE
QUATERNARY STEREOCENTERS
ORGANOCATALYSIS
ALPHA,BETA-UNSATURATED AMIDES
ALDEHYDES
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Summary:The asymmetric intermolecular Stetter reaction is catalyzed by a novel triazolium salt derived N-heterocyclic carbene leading to 1,4-diketones in moderate to excellent yields (49-98%) and moderate to good enantioselectivities (56-78% ee), which could be enhanced by one recrystallization to excellent levels (90-99% ee).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/b809913h