Altereporenes A–E, five epoxy octa-hydronaphthalene polyketides produced by an endophytic fungus Alternaria sp. YUD20002

Five previously undescribed epoxy octa-hydronaphthalene polyketides, altereporenes A–E (1–5) were isolated from rice culture of the endophytic fungus Alternaria sp. YUD20002 derived from the tubers of Solanum tuberosum . Their structures were determined on the basis of comprehensive spectroscopic an...

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Published inRSC advances Vol. 12; no. 34; pp. 22295 - 22301
Main Authors Xia, Dan-Dan, Duan, Hao-Jie, Xie, Fei, Xie, Tian-Peng, Zhang, Yan, Sun, Yue, Lu, Jian-Mei, Gao, Yu-Hong, Zhou, Hao, Ding, Zhong-Tao
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 10.08.2022
The Royal Society of Chemistry
Subjects
acetylcholinesterase
Alternaria
Antiinfectives and antibacterials
Chemistry
cytotoxicity
endophytes
epoxides
Fungi
polyketides
rice
Solanum tuberosum
spectroscopy
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Summary:Five previously undescribed epoxy octa-hydronaphthalene polyketides, altereporenes A–E (1–5) were isolated from rice culture of the endophytic fungus Alternaria sp. YUD20002 derived from the tubers of Solanum tuberosum . Their structures were determined on the basis of comprehensive spectroscopic analyses, while the absolute configurations were elucidated by the comparison of experimental and calculated specific rotations. Meanwhile, the antimicrobial, cytotoxic, anti-inflammatory and acetylcholinesterase inhibitory activities of compounds 1–5 were also investigated.
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ISSN:2046-2069
2046-2069
DOI:10.1039/D2RA03917F