Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase deficiency in the Saudi population

The frequencies of glucose-6-phosphate dehydrogenase (G-6-PD), pyruvate kinase (PK) and hexokinase (HK) deficiency were determined in different regions of Saudi Arabia. G-6-PD deficiency was found to range from 0.045 to 0.220 for the male and 0.020 to 0.125 for the female population. The highest fre...

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Bibliographic Details
Published inHuman heredity Vol. 36; no. 1; p. 45
Main Authors el-Hazmi, M A, Al-Swailem, A R, Al-Faleh, F Z, Warsy, A S
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1986
Subjects
Carbohydrate Metabolism, Inborn Errors - epidemiology
Carbohydrate Metabolism, Inborn Errors - genetics
Demography
Female
Gene Frequency
Glucosephosphate Dehydrogenase Deficiency - epidemiology
Glucosephosphate Dehydrogenase Deficiency - genetics
Hexokinase - deficiency
Humans
Male
Pyruvate Kinase - deficiency
Saudi Arabia
Sex Factors
Saudi Arabia
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Summary:The frequencies of glucose-6-phosphate dehydrogenase (G-6-PD), pyruvate kinase (PK) and hexokinase (HK) deficiency were determined in different regions of Saudi Arabia. G-6-PD deficiency was found to range from 0.045 to 0.220 for the male and 0.020 to 0.125 for the female population. The highest frequencies were found to exist in the regions which are endemic to malarial parasite and have high frequencies of sickle cell and thalassaemia genes. Partial deficiencies of PK and HK were encountered in each region, however, no case of complete deficiency of these enzymes was identified. Further investigations are in progress to determine the clinical manifestations of enzyme deficiencies in the Saudi population.
ISSN:0001-5652
DOI:10.1159/000153599