Characterization of the 3' terminal region of the large molecular weight RNA subunits from normal and transformation defective Rous sarcoma virus

In avian sarcoma viruses a function required to transform cells is frequently lost giving rise to non-transforming virus. The genetic information for this function is localized near the 3' end of the genome. Short 3'-terminal poly(A)-linked RNA fragments from the genomes of a transforming...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 454; no. 2; pp. 383 - 388
Main Authors Perez-Bercoff, R, Billeter, M.A
Format Journal Article
LanguageEnglish
Published Netherlands 01.12.1976
Subjects
animal diseases
animal health
Avian Sarcoma Viruses - analysis
Cell Transformation, Neoplastic
Oligonucleotides - analysis
Poly A - analysis
RNA, Viral - analysis
Structure-Activity Relationship
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Summary:In avian sarcoma viruses a function required to transform cells is frequently lost giving rise to non-transforming virus. The genetic information for this function is localized near the 3' end of the genome. Short 3'-terminal poly(A)-linked RNA fragments from the genomes of a transforming Rous sarcoma virus and its non-transforming derivative were isolated and gave rise to identical fingerprint patterns, suggesting that internal deletion rather than terminal elimination leads to non-transforming virus.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0006-3002
1878-2434
DOI:10.1016/0005-2787(76)90240-9