Antinociceptive Effect of Dendrobii caulis in Paclitaxel-Induced Neuropathic Pain in Mice

• Published in: Life (Basel, Switzerland) Vol. 13; no. 12; p. 2289
• Main Authors: Park, Keun Tae, Jeon, Yong Jae, Kim, Hyo In, Kim, Woojin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.11.2023
• Subjects: Cancer; Capsaicin receptors; Capsazepine; Chemotherapy; Dendrobii caulis; Dendrobium officinale; Drug dosages; Ethanol; Flavonoids; Food sources; Gene expression; Herbal medicine; High performance liquid chromatography; Inflammatory bowel disease; Liquid chromatography; Neuralgia; Oral administration; Paclitaxel; Pain; Pain perception; Receptors; Ribonucleic acid; RNA; Spinal cord; Transient receptor potential proteins; transient receptor potential vanilloid 1; Tumor necrosis factor-TNF; South Korea; St Louis Missouri; United States > US; China; paclitaxel; Dendrobium officinale; Dendrobii caulis; transient receptor potential vanilloid 1
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life13122289

Paclitaxel-induced neuropathic pain (PINP) is a serious adverse effect of chemotherapy. ( ) is a new food source used as herbal medicine in east Asia. We examined the antinociceptive effects of extract on PINP and clarified the mechanism of action of transient receptor potential vanilloid 1 receptor (TRPV1) in the spinal cord. PINP was induced in male mice using multiple intraperitoneal injections of paclitaxel (total dose, 8 mg/kg). PINP was maintained from D10 to D21 when assessed for cold and mechanical allodynia. Oral administration of 300 and 500 mg/kg relieved cold and mechanical allodynia. In addition, TRPV1 in the paclitaxel group showed increased gene and protein expression, whereas the 300 and 500 mg/kg groups showed a significant decrease. Among various substances in , vicenin-2 was quantified by high-performance liquid chromatography, and its administration (10 mg/kg, i.p.) showed antinociceptive effects similar to those of 500 mg/kg. Administration of the TRPV1 antagonist capsazepine also showed antinociceptive effects similar to those of , and is thought to exhibit antinociceptive effects on PINP by modulating the spinal TRPV1.