Recovery of potassium clavulanate from fermentation broth by ion exchange chromatography and desalting electrodialysis

• Published in: Biotechnology and bioprocess engineering Vol. 14; no. 6; pp. 803 - 810
• Main Authors: Kim, Hyun Han, Kang, Sang Hyeon, Chang, Yong Keun
• Format: Journal Article
• Language: English
• Published: Heidelberg The Korean Society for Biotechnology and Bioengineering 01.12.2009; Springer Nature B.V; 한국생물공학회
• Subjects: Antibiotics; Bioengineering; Biotechnology; By products; Chemical reactions; Chemistry; Chemistry and Materials Science; Chromatography; Electrodialysis; Equilibrium; Experiments; Feed composition; Fermentation; Flow rates; Hemodialysis; Industrial and Production Engineering; Ion exchange; Potassium; Solvent extraction processes; Studies; 생물공학; ion exchange chromatography (IEC); desaiting electrodialysis (DSED); potassium clavulanate (KCA); fermentation broth

Ion exchange chromatography (IEC) and desalting electrodialysis (DSED) processes were developed for the recovery and purification of potassium clavulanate (KCA) from fermentation broth. A strong anion exchanger, Amberlite IRA 400 resin, a potassium acetate solution as equilibrium buffer, and a potas...