Association of MHC class II–peptide complexes with plasma membrane lipid microdomains

Activation of CD4 + T cells requires the interaction of multiple T-cell receptors with MHC class II–peptide complexes on the surface of antigen-presenting cells (APCs). Recent studies have shown that MHC class II complexes are clustered in APC plasma membrane microdomains, thereby providing a mechan...

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Bibliographic Details
Published inCurrent opinion in immunology Vol. 16; no. 1; pp. 103 - 107
Main Authors Poloso, Neil J, Roche, Paul A
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2004
Subjects
Animals
Antigen Presentation
CD4 antigen
CD4 Antigens - physiology
Histocompatibility Antigens Class II - physiology
Membrane Microdomains - immunology
Membrane Proteins - metabolism
Models, Immunological
Peptides - immunology
Peptides - metabolism
T-Lymphocytes - immunology
GFP
pMHC-II
TCR
APC
DC
mAb
MHC-II
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Summary:Activation of CD4 + T cells requires the interaction of multiple T-cell receptors with MHC class II–peptide complexes on the surface of antigen-presenting cells (APCs). Recent studies have shown that MHC class II complexes are clustered in APC plasma membrane microdomains, thereby providing a mechanism for localized concentration of MHC class II–peptide complexes. The integrity of one type of APC membrane microdomain, the lipid raft, is important for antigen presentation to T cells. We propose a model in which the coordinated processes of MHC class II peptide loading and intracellular trafficking enhance T-cell activation by loading specific MHC class II–peptide complexes in discrete lipid raft microdomains.
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ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2003.11.009