Fungemia due to Fusarium solani under low-dose liposomal amphotericin B in a patient after cord blood transplantation

• Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 25; no. 8; pp. 635 - 638
• Main Authors: Konuma, Takaaki, Takahashi, Shunsuke, Kiyuna, Tomohiko, Misawa, Yoshiki, Suzuki, Masato, Isobe, Masamichi, Jimbo, Koji, Mizusawa, Mai, Kato, Seiko, Takahashi, Satoshi, Tojo, Arinobu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2019
• Subjects: Aged; Allogeneic hematopoietic stem cell transplantation; Amphotericin B - adverse effects; Antifungal Agents - adverse effects; Cord Blood Stem Cell Transplantation; Cord blood transplantation; Fugemia; Fungemia - drug therapy; Fungemia - microbiology; Fusarium - pathogenicity; Fusarium solani; Humans; Internal transcribed spacer region; Liposomal amphotericin B; Male; Fusarium solani; Liposomal amphotericin B; Allogeneic hematopoietic stem cell transplantation; Internal transcribed spacer region; Fugemia; Cord blood transplantation
• ISSN: 1341-321X; 1437-7780
• DOI: 10.1016/j.jiac.2019.02.020

The introduction of the prophylactic use of antifungal drugs caused the increased occurrence of invasive fungal infections due to previously rare molds, such as fusariosis, after allogeneic hematopoietic stem cell transplantation. We herein report the case of a patient with diffuse large B-cell lymphoma who developed fungemia due to Fusarium solani during liposormal amphotericin B on day 25 after cord blood transplantation (CBT). Because Fusarium species might differ in virulence and drug susceptibility, the sequencing of the internal transcribed spacer region of the ribosomal RNA gene accurately identified Fusarium solani to be the cause of fungemia at the species level. This case highlights Fusarium solani as the cause of fungemia in a patient under liposormal amphotericin B treatment after CBT.