Ultrasound Shear Wave Attenuation Imaging for Grading Liver Steatosis in Volunteers and Patients With Non-alcoholic Fatty Liver Disease: A Pilot Study

• Published in: Ultrasound in medicine & biology Vol. 49; no. 10; pp. 2264 - 2272
• Main Authors: Yazdani, Ladan, Rafati, Iman, Gesnik, Marc, Nicolet, Frank, Chayer, Boris, Gilbert, Guillaume, Volniansky, Anton, Olivié, Damien, Giard, Jeanne-Marie, Sebastiani, Giada, Nguyen, Bich N., Tang, An, Cloutier, Guy
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.10.2023
• Subjects: Attenuation; Biopsy; Cutoff threshold; Dispersion; Elastography; Liver steatosis; Magnetic resonance imaging proton density fat fraction; Non-alcoholic fatty liver disease; Shear wave; Ultrasound; Cutoff threshold; Biopsy; Magnetic resonance imaging proton density fat fraction; Attenuation; Shear wave; Non-alcoholic fatty liver disease; Ultrasound; Elastography; Dispersion; Liver steatosis
• ISSN: 0301-5629; 1879-291X
• DOI: 10.1016/j.ultrasmedbio.2023.06.020

The aims of the work described here were to assess shear wave attenuation (SWA) in volunteers and patients with non-alcoholic fatty liver disease (NAFLD) and compare its diagnostic performance with that of shear wave dispersion (SWD), magnetic resonance imaging (MRI) proton density fat fraction (PDFF) and biopsy. Forty-nine participants (13 volunteers and 36 NAFLD patients) were enrolled. Ultrasound and MRI examinations were performed in all participants. Biopsy was also performed in patients. SWA was used to assess histopathology grades as potential confounders. The areas under curves (AUCs) of SWA, SWD and MRI-PDFF were assessed in different steatosis grades by biopsy. Youden's thresholds of SWA were obtained for steatosis grading while using biopsy or MRI-PDFF as the reference standard. Spearman's correlations of SWA with histopathology (steatosis, inflammation, ballooning and fibrosis) were 0.89, 0.73, 0.62 and 0.31, respectively. Multiple linear regressions of SWA confirmed the correlation with steatosis grades (adjusted R2 = 0.77, p < 0.001). The AUCs of MRI-PDFF, SWA and SWD were respectively 0.97, 0.99 and 0.94 for S0 versus ≥S1 (p > 0.05); 0.94, 0.98 and 0.78 for ≤S1 versus ≥S2 (both MRI-PDFF and SWA were higher than SWD, p < 0.05); and 0.90, 0.93 and 0.68 for ≤S2 versus S3 (both SWA and MRI-PDFF were higher than SWD, p < 0.05). SWA's Youden thresholds (Np/m/Hz) (sensitivity, specificity) for S0 versus ≥S1, ≤S1 versus ≥S2 and ≤S2 versus S3 were 1.05 (1.00, 0.92), 1.37 (0.96, 0.96) and 1.51 (0.83, 0.87), respectively. These values were 1.16 (1.00, 0.81), 1.49 (0.91, 0.82) and 1.67 (0.87, 0.92) when considering MRI-PDFF as the reference standard. In this pilot study, SWA increased with increasing steatosis grades, and its diagnostic performance was higher than that of SWD but equivalent to that of MRI-PDFF.