Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes

Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chro...

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Bibliographic Details
Published inBlood Vol. 85; no. 5; pp. 1169 - 1174
Main Authors LAFAGE-POCHITALOFF, M, ALCALAY, M, BRUNEL, V, LONGO, L, SAINTY, D, SIMONETTI, J, BIRG, F, PELICCI, P. G
Format Journal Article
LanguageEnglish
Published Washington, DC The Americain Society of Hematology 01.03.1995
Subjects
Base Sequence
Biological and medical sciences
Chromosomes, Human, Pair 15 - ultrastructure
Chromosomes, Human, Pair 17 - ultrastructure
DNA, Neoplasm - genetics
Female
Hematologic and hematopoietic diseases
Humans
In Situ Hybridization, Fluorescence
Leukemia, Promyelocytic, Acute - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Molecular Sequence Data
Neoplasm Proteins - genetics
Neoplasm Proteins - physiology
Nuclear Proteins
Oncogene Proteins, Fusion - genetics
Oncogene Proteins, Fusion - physiology
Promyelocytic Leukemia Protein
Receptors, Retinoic Acid - genetics
Retinoic Acid Receptor alpha
Transcription Factors - genetics
Translocation, Genetic
Tumor Suppressor Proteins
Chromosomal aberration
Human
Promyelocytic leukemia
Molecular hybridization
Acute
In situ
Abnormal chromosome
Exploration
Malignant hemopathy
Retinoic acid
Chromosome translocation
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Summary:Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciprocal RARa/PML. We report APL cases with submicroscopic 15;17 recombinations leading to the formation of nonreciprocal PML/RARa or RARa/PML fusion genes. Therefore, each of the two reciprocal translocation products may be independently formed and selected by the leukemic phenotype, implying that both are involved in tumorigenesis.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.v85.5.1169.1169