HPTLC Screening of Weight Loss Products for Deliberately Added Undeclared Synthetic Drugs

The proposed HPTLC method combines features of the existing methods for ( ) the detection of sibutramine and ( ) for the detection of phosphodiesterase type 5 inhibitors and analogs. The method permits effective screening for the presence of nine adulterants in finished products, including tablets,...

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Bibliographic Details
Published inJournal of AOAC International Vol. 102; no. 3; pp. 776 - 780
Main Authors Do, Tiên T K, Reich, Eike
Format Journal Article
LanguageEnglish
Published England AOAC International 01.05.2019
Subjects
Anti-obesity agents
Anti-Obesity Agents - analysis
Backup software
Chromatography, Thin Layer - methods
Composition
Densitometry
Diet industry
Dietary Supplements - analysis
Drug Contamination - prevention & control
Drugs
Enzyme inhibitors
Food Contamination - analysis
Measurement
Methanol
Organic Chemicals - analysis
Phenolphthalein
Sibutramine
Synthetic Drugs - analysis
Testing
Ultrasound
Vardenafil
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Summary:The proposed HPTLC method combines features of the existing methods for ( ) the detection of sibutramine and ( ) for the detection of phosphodiesterase type 5 inhibitors and analogs. The method permits effective screening for the presence of nine adulterants in finished products, including tablets, capsules, and "instant coffee" powders. All products were prepared for analysis using the same simple procedure: ultrasound-assisted extraction in methanol for 30 min followed by centrifugation or filtration. The retardation factor ) values of individual zones afford preliminary identification of potential adulterants. Scanning densitometry enables comparison of recorded UV spectra with those of known standard compounds and provides further structural information. The method was successfully applied to 12 commercial products. Of those, nine products tested positive for at least one undeclared component.
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ISSN:1060-3271
1944-7922
DOI:10.5740/jaoacint.18-0263