Survival After Lung Transplant for Cystic Fibrosis in Italy: A Single Center Experience With 20 Years of Follow-up

• Published in: Transplantation proceedings Vol. 50; no. 10; pp. 3732 - 3738
• Main Authors: Savi, D., Mordenti, M., Bonci, E., Troiani, P., Giordani, B., D’Alù, V., Bertasi, S., Cimino, G., Rossi, P., Poggi, C., Palange, P., Quattrucci, S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2018
• Subjects: Adolescent; Adult; Child; Cystic Fibrosis - mortality; Cystic Fibrosis - surgery; Female; Follow-Up Studies; Humans; Italy; Kaplan-Meier Estimate; Lung Transplantation - methods; Lung Transplantation - mortality; Male; Middle Aged; Retrospective Studies; Young Adult; Italy
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2018.08.020

Lung transplantation is currently the only treatment for end-stage respiratory failure in patients with cystic fibrosis (CF). In this study we retrospectively analyzed our experience since the start of the transplantation program in 1996 with focus on survival analysis. All patients with CF who underwent lung transplant at our center were included (1996–2016). Survival analysis after lung transplant was performed using the Kaplan-Meier estimate, comparing by sex and by 4 eras (1996–2000, 2001–2005, 2006–2010, and 2011–2016). In a 20-year period, 243 patients with CF were listed for lung transplant; 123 patients (61 male, 62 female) underwent transplant, and 85 died while waiting for donor organs. The mean (SD) and median age at transplant was 27.7 (8.7) years and 26.9 years (range, 9.1 – 52.1 years), respectively. Mean (SD) forced expiratory volume in the first second was 27.6 (9.7)% predicted; 115 patients (92.0%) were pancreatic insufficient, and 43 patients (34.0%) had CF-related diabetes. Removing patients with CF who died within the first 3 postoperative months, the mean (SD) and median survival after transplant were 8.2 (5.7) years and 7.5 years (range, 3 months-20 years), respectively. Overall post–lung transplant 1-year survival was 93.6%, 5-year survival was 71.4%, 10-year survival was 53.6%, 15-year survival was 36.7%, and 20-year survival was 31.6%. We found no difference in survival between sex (P = .22) and among the 4 eras (P = .56). Survival after lung transplant in our single center is similar to international data.