Capillary Electrophoresis with Laser Induced Fluorescence Detection for Study of the Association of HSP60 Gene Polymorphism with Gouty Arthritis

• Published in: Journal of AOAC International Vol. 102; no. 3; pp. 810 - 814
• Main Authors: Ren, Dongxia, Fan, Min, Sun, Chengjun, Zhou, Chen, Li, Yongxin
• Format: Journal Article
• Language: English
• Published: England AOAC International 01.05.2019
• Subjects: Adult; Arthritis; Arthritis, Gouty - genetics; Backup software; Chaperonin 60 - genetics; Deoxyribonucleases, Type II Site-Specific - chemistry; DNA; DNA - analysis; DNA - genetics; EDTA; Electrophoresis; Electrophoresis, Capillary - methods; Female; Fluorescence; Genes; Genetic aspects; Genetic polymorphisms; Gout; Health; Health aspects; Heat shock proteins; Humans; Male; Middle Aged; Mitochondrial Proteins - genetics; Nucleases; Nucleic acids; Polymorphism, Genetic; Regression Analysis; Risk factors

Background: Gout arthritis is a common inflammatory arthritis and it poses a major threat to human health. Objective: A method of capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) for the detection of HSP60 gene polymorphism has been developed and applied to the exploratio...