Right Extended Split Liver Transplantation Compared With Whole Liver Transplantation: Lessons Learned at a Single Center in Latin America—Results From a Match Case-Control Study

• Published in: Transplantation proceedings Vol. 49; no. 9; pp. 2122 - 2128
• Main Authors: Gambaro, S.E., Romero, P., Pedraza, N., Moulin, L., Yantorno, S., Ramisch, D., Rumbo, C., Barros-Schelotto, P., Descalzi, V., Gondolesi, G.E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017
• Subjects: Adolescent; Adult; Aged; Argentina; Case-Control Studies; Cold Ischemia; Female; Humans; Liver Diseases - pathology; Liver Diseases - surgery; Liver Transplantation - methods; Liver Transplantation - mortality; Male; Middle Aged; Postoperative Complications - etiology; Postoperative Complications - mortality; Retrospective Studies; Severity of Illness Index; Survival Rate; Tissue Donors - supply & distribution; Treatment Outcome; Waiting Lists; Young Adult
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2017.07.019

Despite the progressively increasing gap between patients waiting for liver transplant under the Model for End-stage Liver Disease MELD system and the availability of deceased donor organs, the use of right extended split liver grafts (RESLG) has not been accepted by all centers. In this study, we compared the results obtained using RESLG vs a group of matched whole liver graft (WLG) recipients at a single center in Latin America. A single-center retrospective review performed between August 2009 and December 2015. Fifteen RESLGs were implanted to recipients between 13 and 70 years of age; 80% were performed ex situ. The “biological MELD” score for the RESLG group was 17.5 ± 5.6, and it was 12.8 ± 4.5 for the WLG group (P = .01). Cold ischemia times were significantly longer in RESLG recipients compared with WLG recipients (528 minutes vs 420 minutes; P < .01). No significant differences were found in biliary (leak or strictures P = .40) and arterial complications (hepatic artery thrombosis, P = .06). RESLG patients benefited from a considerable reduction on their waiting time in list. The 1-, 3-, and 5-year patient survival rates were 93%, 93%, and 93% respectively, for RESLG recipients vs 100%, 95.7%, and 86.1%, respectively, for WLG recipients. The 1-, 3-, and 5-year graft survival rates were 79.4%, 79.4%, and 79.4% for RESLG recipients and 89.7%, 89.7%, and 89.7% for WLG recipients, respectively. No statistical differences were observed. RESLG allows expeditious transplantation for low MELD recipients. Its use should be expanded in Latin America and worldwide as a valid alternative to increase the donor pool as it has been used in other regions. •The RESLG should be an alternative to reduce the gap between patients waiting for liver transplant and cadaveric donor availability.•Comparable patients and graft survival can be achieved with acceptable complications.•Split recipients benefited from having a reduced time in the waiting list.•The split procedure should be promoted worldwide.