RADSeq: next-generation population genetics

Next-generation sequencing technologies are making a substantial impact on many areas of biology, including the analysis of genetic diversity in populations. However, genome-scale population genetic studies have been accessible only to well-funded model systems. Restriction-site associated DNA seque...

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Bibliographic Details
Published inBriefings in functional genomics Vol. 9; no. 5-6; pp. 416 - 423
Main Authors Davey, J. W., Blaxter, M. L.
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.12.2010
Subjects
Animals
Base Sequence
Genetic Variation
Genetics, Population
Genome
Humans
Phylogeny
Polymorphism, Single Nucleotide
Restriction Mapping
Sequence Analysis, DNA - methods
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Summary:Next-generation sequencing technologies are making a substantial impact on many areas of biology, including the analysis of genetic diversity in populations. However, genome-scale population genetic studies have been accessible only to well-funded model systems. Restriction-site associated DNA sequencing, a method that samples at reduced complexity across target genomes, promises to deliver high resolution population genomic data-thousands of sequenced markers across many individuals-for any organism at reasonable costs. It has found application in wild populations and non-traditional study species, and promises to become an important technology for ecological population genomics.
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ISSN:2041-2649
2041-2657
2041-2657
DOI:10.1093/bfgp/elq031