The influence of gene-chronic hepatitis C virus infection on hepatic fibrosis and steatosis

• Published in: Diagnostic microbiology and infectious disease Vol. 97; no. 2; p. 115025
• Main Authors: Magri, Mariana Cavalheiro, Manchiero, Caroline, Prata, Thamiris Vaz Gago, Nunes, Arielle Karen da Silva, Oliveira Junior, José Santos de, Dantas, Bianca Peixoto, Tengan, Fátima Mitiko
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2020
• Subjects: Adult; Aged; Brazil; Carrier Proteins - genetics; Fatty Liver - genetics; Fatty Liver - virology; Female; Genetic Association Studies; Genotype; Hepacivirus - genetics; Hepacivirus - pathogenicity; Hepatitis C; Hepatitis C, Chronic - genetics; Hepatitis C, Chronic - virology; Humans; Interferon lambda 3 and 4 (IFNL3/IFNL4); Interferons - genetics; Lipase - genetics; Liver Cirrhosis - genetics; Liver Cirrhosis - virology; Male; Membrane Proteins - genetics; Microsomal triglyceride transfer protein (MTTP); Middle Aged; Patatin-like phospholipase domain containing 3 (PNPLA3); Polymorphism, Single Nucleotide; Single nucleotide polymorphisms (SNPs); Transmembrane six superfamily member 2 (TM6SF2); Brazil; AST; NAFLD; OR; Transmembrane six superfamily member 2 (TM6SF2); CI; MTTP; ALT; HCC; Single nucleotide polymorphisms (SNPs); Microsomal triglyceride transfer protein (MTTP); IL28; TM6SF2; Interferon lambda 3 and 4 (IFNL3/IFNL4); HOMA-IR; Patatin-like phospholipase domain containing 3 (PNPLA3); IFNL3/IFNL4; GGT; PNPLA3; SNPs; HCV; Hepatitis C; PCR; BMI; CHC
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/j.diagmicrobio.2020.115025

Host single nucleotide polymorphisms (SNPs) in different genes can play a role in chronic hepatitis C virus (HCV) infection and influence the presence of hepatic fibrosis and comorbidities such as hepatic steatosis. We assessed the combined effect of SNPs in the PNPLA3, MTTP, TM6SF2, and IFNL3/IFNL4 genes in 288 Brazilian patients who were chronically infected with HCV. Hepatic fibrosis was observed in 246 (85.4%) patients and hepatic steatosis in 141 (49.0%) patients. PNPLA3 rs738409 (CG/GG) (P = 0.044) and TM6SF2 rs58542926 (CT) (P = 0.004) were alone associated with fibrosis, and PNPLA3 rs738409 (P < 0.05, in distinct genetic models) was associated with steatosis. Multiple logistic regression of each SNP combined with HCV genotype 3 infection showed that MTTP rs1800591 (GT/TT) combined with HCV genotype 3 was associated with a 6.72-fold increased chance of hepatic steatosis (P = 0.013). In the analysis of SNPs combined 2 by 2, no influence on hepatic fibrosis or steatosis was observed.