Non-association of Crohn's disease with NOD2 gene variants in Moroccan patients

• Published in: Gene Vol. 499; no. 1; pp. 121 - 123
• Main Authors: Hama, I., Ratbi, I., Reggoug, S., Elkerch, F., Kharrasse, G., Errabih, I., Ouazzani, H., Sefiani, A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.05.2012
• Subjects: Adolescent; Adult; alleles; Case-Control Studies; chronic diseases; Crohn disease; Crohn Disease - epidemiology; Crohn Disease - genetics; Crohn's disease; Female; gastrointestinal system; gene frequency; Genetic Association Studies; Genetics, Population; genotype; genotyping; Humans; innate immunity; intracellular signaling peptides and proteins; Male; meta-analysis; Middle Aged; Moroccan population; Morocco - epidemiology; Nod2 Signaling Adaptor Protein - genetics; NOD2/CARD15; patients; Pilot Projects; Polymorphism, Genetic - physiology; single nucleotide polymorphism; Variant; Young Adult; Morocco; NOD2/CARD15; Variant; CD; OR; CI; Moroccan population; IBD; Crohn's disease; NOD2; PCR

Crohn's disease is a chronic inflammatory bowel disease, with multifactorial traits, that can involve any part of the gastrointestinal tract. In recent years, a dozen genome-wide association scan and meta-analysis were published bringing the number of susceptibility alleles to more than 30 vari...