Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb

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Bibliographic Details
Published inCell death and differentiation Vol. 10; no. 8; pp. 930 - 932
Main Authors Lauricella, M, D'Anneo, A, Giuliano, M, Calvaruso, G, Emanuele, S, Vento, R, Tesoriere, G
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.08.2003
Subjects
Acetylcysteine - analogs & derivatives
Acetylcysteine - pharmacology
Amino Acid Chloromethyl Ketones - pharmacology
Antioxidants - pharmacology
Apoptosis - drug effects
bcl-X Protein
Blotting, Western
Caspase 3
Caspase 8
Caspases - drug effects
Caspases - metabolism
Cell Line, Tumor - drug effects
Cell Survival - drug effects
Cysteine Endopeptidases
Cytochromes c - drug effects
Cytochromes c - secretion
Dose-Response Relationship, Drug
Flow Cytometry
Humans
Leupeptins - pharmacology
Membrane Potentials - drug effects
Microscopy, Fluorescence
Mitochondria - drug effects
Mitochondria - physiology
Multienzyme Complexes - antagonists & inhibitors
Osteosarcoma - metabolism
Osteosarcoma - pathology
Protease Inhibitors - pharmacology
Proteasome Endopeptidase Complex
Proto-Oncogene Proteins c-bcl-2 - drug effects
Proto-Oncogene Proteins c-bcl-2 - metabolism
Reactive Oxygen Species - metabolism
Retinoblastoma Protein - genetics
Retinoblastoma Protein - physiology
Time Factors
Transfection
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - physiology
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Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:1350-9047
1476-5403
DOI:10.1038/sj.cdd.4401251