Evaluating the Efficacy of Resect-and-Discard and Resect-and-Retrieve Strategies for Diminutive Colonic Polyps

• Published in: Life (Basel, Switzerland) Vol. 14; no. 4; p. 532
• Main Authors: Groza, Andrei Lucian, Miutescu, Bogdan, Tefas, Cristian, Popa, Alexandru, Ratiu, Iulia, Sirli, Roxana, Popescu, Alina, Motofelea, Alexandru Catalin, Tantau, Marcel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.04.2024
• Subjects: Age; Cancer; colon polyps; Colonoscopy; colorectal cancer; Colorectal carcinoma; colorectal surgery; Data collection; Endoscopy; gastroenterology; Gastrointestinal symptoms; Medical imaging; Normal distribution; Polyps; Prevention; Regression analysis; Statistical analysis; Surveillance; Japan; colorectal surgery; colon polyps; colorectal cancer; gastroenterology
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life14040532

Diminutive polyps present a unique challenge in colorectal cancer (CRC) prevention strategies. This study aims to assess the characteristics and variables of diminutive polyps in a Romanian cohort, intending to develop a combined resect-and-retrieve or resect-and-discard strategy that reduces the need for an optical diagnosis. A prospective cohort study was conducted at two endoscopy centers in Romania from July to December 2021. Adult patients undergoing colonoscopies where polyps were identified and resected were included. Endoscopic procedures employed advanced diagnostic features, including blue-light imaging (BLI) and narrow-band imaging (NBI). Logistic regression analysis was utilized to determine factors impacting the probability of adenomatous polyps with high-grade dysplasia (HGD). A total of 427 patients were included, with a mean age of 59.42 years (±11.19), predominantly male (60.2%). The most common indication for a colonoscopy was lower gastrointestinal symptoms (42.6%), followed by screening (28.8%). Adequate bowel preparation was achieved in 87.8% of cases. The logistic regression analysis revealed significant predictors of HGD in adenomatous polyps: age (OR = 1.05, 95% CI: 1.01-1.08, = 0.01) and polyp size (>5 mm vs. ≤5 mm, OR = 4.4, 95% CI: 1.94-10.06, < 0.001). Polyps classified as Paris IIa, Ip, and Isp were significantly more likely to harbor HGD compared to the reference group (Is), with odds ratios of 6.05, 3.68, and 2.7, respectively. The study elucidates significant associations between the presence of HGD in adenomatous polyps and factors such as age, polyp size, and Paris classification. These findings support the feasibility of a tailored approach in the resect-and-discard and resect-and-retrieve strategies for diminutive polyps, potentially optimizing CRC prevention and intervention practices. Further research is warranted to validate these strategies in broader clinical settings.