Long-term results of vagus nerve stimulation in refractory epilepsy

• Published in: Seizure (London, England) Vol. 8; no. 6; pp. 328 - 334
• Main Authors: Vonck, K, Boon, P, D’Havé, M, Vandekerckhove, T, O’Connor, S, De Reuck, J
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.1999
• Subjects: Adolescent; Adult; Anticonvulsants - therapeutic use; complex partial seizures; Electric Stimulation Therapy - adverse effects; Electric Stimulation Therapy - instrumentation; Electric Stimulation Therapy - methods; epilepsy surgery; Epilepsy, Complex Partial - diagnosis; Epilepsy, Complex Partial - drug therapy; Epilepsy, Complex Partial - therapy; Female; Follow-Up Studies; Humans; long-term treatment; Male; Prostheses and Implants; refractory epilepsy; seizure-free; Vagus Nerve; vagus nerve stimulation; long-term treatment; epilepsy surgery; vagus nerve stimulation; seizure-free; complex partial seizures; refractory epilepsy
• ISSN: 1059-1311; 1532-2688
• DOI: 10.1053/seiz.1999.0299

Vagus nerve stimulation (VNS) is an adjunctive antiepileptic treatment for patients with refractory epilepsy. Limited information on long-term treatment with VNS is available. The purpose of this paper is to present our experience with VNS with a follow-up of up to 4 years. Twenty-five patients (13 females and 12 males) with refractory partial epilepsy were treated with VNS. The first 15 patients with a mean age of 30 years and a mean duration of epilepsy of 17.5 years have sufficient follow-up for analysis. Mean post-implantation follow-up was 29 months and mean stimulation output 2.25 mA. There was a mean seizure frequency reduction from 14 complex partial seizures (CPS) per month before implantation to 8 CPS per month after implantation (P= 0.0016; Wilcoxon signed-rank rest (WSRT)). The mean maximum CPS-free interval changed from 9 to 312 days (P= 0.0007; WSRT). Six patients were free of CPS for at least one year. In one patient, one antiepileptic drug (AED) was tapered; in 10 patients, AEDs remained unchanged; in four, one adjunctive AED was administered. Side effects occurred in six patients, three of whom required a temporary reduction of output current. Nine patients reported no side effects at all. Treatment with VNS remains effective in the long-term. In this series 4/15 (27%) patients with highly refractory epilepsy experienced entirely seizure-free intervals of 12 months or more.