Label-free and naked eye detection of PNA/DNA hybridization using enhancement of gold nanoparticles

Utilizing a gold enhancement process after inducing electrostatic interaction between positively charged gold nanoparticles and negatively charged target DNA hybridized to neutral PNA capture probes, a new method for label-free detection of DNA was developed and successfully applied to detect H5-typ...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 46; no. 19; pp. 3315 - 3317
Main Authors Kim, Sang Kyu, Cho, Hyunmin, Jeong, Jinyoung, Kwon, Ji Na, Jung, Yongwon, Chung, Bong Hyun
Format Journal Article
LanguageEnglish
Published England 01.01.2010
Subjects
DNA - chemistry
Gold - chemistry
In Situ Hybridization
Metal Nanoparticles - chemistry
Particle Size
Peptide Nucleic Acids - chemistry
Static Electricity
Surface Properties
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Summary:Utilizing a gold enhancement process after inducing electrostatic interaction between positively charged gold nanoparticles and negatively charged target DNA hybridized to neutral PNA capture probes, a new method for label-free detection of DNA was developed and successfully applied to detect H5-type DNA.
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ISSN:1359-7345
1364-548X
DOI:10.1039/b926940a