Adenylate cyclases in Physarum polycephalum: Inhibition of a nuclear enzyme by polyamines

Two distinct adenylate cyclase enzymes have been found in Physarum polycephalum. One is derived from isolated nuclei and is potently inhibited by an equimolar combination of the three polyamines, putrescine, spermidine, and spermine. The second enzyme is particulate, derived from the cytoplasmic com...

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Published inBiochemical and biophysical research communications Vol. 68; no. 2; pp. 561 - 568
Main Authors Atmar, V.J., Westland, J.A., Garcia, G., Kuehn, G.D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1976
Subjects
Adenylyl Cyclases - metabolism
Cell Nucleus - drug effects
Cell Nucleus - enzymology
fungi
Kinetics
Myxomycetes - enzymology
Physarum - drug effects
Physarum - enzymology
Putrescine - pharmacology
Spermidine - pharmacology
Spermine - pharmacology
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Summary:Two distinct adenylate cyclase enzymes have been found in Physarum polycephalum. One is derived from isolated nuclei and is potently inhibited by an equimolar combination of the three polyamines, putrescine, spermidine, and spermine. The second enzyme is particulate, derived from the cytoplasmic compartment, and is insensitive to inhibition by the polyamines. These observations support a potential role for the polyamines in the control of adenosine 3′,5′-monophosphate synthesis in P. polycephalum nuclei.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(76)91182-7